Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects.Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeutic PPs are usually administered by parenteral route
To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef.We identified the GPG-motif, located at the 121-137 region of HIV-1 NL4.3 Nef, as a novel protein signature strictly required for the p56Lck dependent Nef-induced CD4-downre
Abstract Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as inflammatory bowel disease and colorectal cancer, and disorder in extraintestinal organs.The mucus layer has attracted the attention of the scientific community in recent years, and with the discov
Most historians agree that the original planimetry of the church in Dealu Frumos consisted of a hall church with nave and two aisles, a square choir, a semicircular apse and a western tower.All these were built during the 13th century, before the Tartar Invasion.During the 14th and 15th centuries (but continued during the 16th century as well) the