Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Blog Article

Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects.Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeutic PPs are usually administered by parenteral route.Given the big demand for oral administration in clinical use, a variety of researches Outdoor Lighting focused on developing new technologies to overcome GI barriers of PPs, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, as well as intestinal microdevices.Some new technologies have been developed under clinical trials and even on the market.

This review summarizes little boys hybrid shorts the history, the physiological barriers and the overcoming approaches, current clinical and preclinical technologies, and future prospects of oral delivery of PPs.